Empirical and anecdotal evidence exists for the following physiological effects of GT:
- Separates and breaks down collagen cross-links, and splays and stretches connective tissue and muscle fibers
- Facilitates reflex changes in the chronic muscle holding pattern (inhibition of abnormal tone/guarding leading to pain reduction via improved sensory input)
- Alters/inhibits spinal reflex activity (facilitated segment)
- Increases the rate and amount of blood flow to and from the area (angiogenesis vs. immediate local increases in blood flow)
- Increases cellular activity in the region, including fibroblasts and mast cells
- Increases histamine response secondary to mast cell activity